NEA Leads $7.5M Seed Funding for Akouos


Akouos, a new biotechnology company focused on restoring and preserving hearing, has closed a $7.5 million seed round led by 5AM Ventures and New Enterprise Associates (NEA), with participation from Partners Innovation Fund. Kush Parmar, managing partner at 5AM Ventures, and Ed Mathers, partner at NEA, join the Akouos board of directors as a result of the investment. Concurrent with the financing, Akouos entered into strategic license agreements with Lonza and Massachusetts Eye and Ear for exclusive rights to the Anc-AAV gene therapy platform for all hearing and balance disorders.

"Our mission is to make healthy hearing available to all," said Dr. Manny Simons, founder and CEO of Akouos. "To this end, we are building the leading inner ear gene therapy company. Our cornerstone partnership with Massachusetts Eye and Ear, the world's largest hearing research center, and with Lonza, a global leader in viral gene and cell therapy manufacturing, sets a strong foundation for the important work to be done in this emergent field."

Anc-AAVs are in silico-designed adeno-associated viral vectors (AAVs), first developed in the laboratory of Dr. Luk H. Vandenberghe, Assistant Professor of Ophthalmology at Harvard Medical School, and Director of the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear. Under the terms of the agreements, Akouos obtains an exclusive field license to the Anc-AAV IP estate and broad sublicensing rights.

Building upon an existing Anc-AAV partnership between Massachusetts Eye and Ear and Lonza, the agreement with Akouos is designed to accelerate AAV gene therapy development for hearing and balance disorders by bringing together world class expertise and resources in hearing science research and development, clinical research, and AAV manufacturing.

"Together with these strategic partners and our founding investors at 5AM Ventures, NEA, and Partners Innovation Fund, Akouos is poised to translate scientific breakthroughs into life-changing treatments," continued Dr. Simons. "We are excited to be working collaboratively with the hearing science research community, hearing health care providers, and families affected by hearing loss to create a future in which the gifts of hearing are available to all."

"This strategic licensing deal with Akouos, alongside our valued partner in Massachusetts Eye and Ear, is a key milestone on the path to delivering the next transformative class of gene therapies together," said Marc Funk, COO, Lonza's Pharma&Biotech segment. "It upholds our commitment at Lonza, the leader and pioneer in global AAV manufacturing, to support world-class innovation in the gene therapy field and our continuous quest for improving patients' lives."

"We are very excited to bring together such great talent to accelerate the progress in treatment of hearing and balance restoration disorders," said D. Bradley Welling, M.D., Ph.D., Chief of Otolaryngology at Massachusetts Eye and Ear and Massachusetts General Hospital and the Walter Augustus LeCompte Professor and Chair of Otolaryngology at Harvard Medical School and Joan W. Miller, M.D., Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital, and the David Glendenning Cogan Professor of Ophthalmology and Chair of Ophthalmology at Harvard Medical School. "It is our mission to make a difference in the lives of patients."

About Akouos

Akouos is a biotechnology company focused on restoring and preserving hearing. Akouos's scientific founders are world leaders in the fields of neurotology, genetics, inner ear drug delivery, and AAV gene therapy:

  • Michael J. McKenna, M.D., is a world-renowned neurotologist with expertise in translational inner ear drug delivery research. He holds the Joseph B. Nadol, Jr. Chair and is the director of the Division of Otology and Neurotology at Massachusetts Eye and Ear, and is a professor of otolaryngology at Harvard Medical School.
  • William F. Sewell, Ph.D., is a leading expert in inner ear drug delivery and pharmacokinetics. He is professor of otolaryngology at Massachusetts Eye and Ear and Harvard Medical School.
  • Richard H. Smith, M.D., is recognized globally as the leading physician-scientist in the field of hereditary hearing loss. He is director of the Molecular Otolaryngology and Renal Research Laboratories and professor of otolaryngology, pediatrics, and molecular physiology and biophysics at the University of Iowa.
  • Luk H. Vandenberghe, Ph.D., is distinguished for his breakthroughs in the AAV field, including the discovery and characterization of new AAV serotypes, and improved understanding of immune responses to AAV vectors. He is director of the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear and assistant professor of ophthalmology at Harvard Medical School.

Akouos launched in 2017 with funding from 5AM Ventures, NEA, and Partners Innovation Fund. Further information can be found at

Disclosure: Drs. McKenna, Sewell, Smith, and Vandenberghe hold equity and serve on the Scientific Advisory Board of Akouos. In addition, Dr. Vandenberghe is a listed inventor on Anc-AAV intellectual property licensed to Lonza and Akouos for which he receives royalties.

About Lonza

Following the closing of the Capsugel acquisition, Lonza further strengthened its position as one of the world's leading and most-trusted suppliers to the pharmaceutical, biotech and specialty ingredients markets. Lonza harnesses science and technology to create products that support safer and healthier living and that enhance the overall quality of life.

An integrated solutions provider serving the healthcare continuum, Lonza offers products and services from the custom development and manufacturing of active pharmaceutical ingredients to innovative dosage forms for the pharma and consumer health and nutrition industries. In addition to drinking water sanitizers, nutraceuticals, antidandruff agents and other personal care ingredients, the company provides agricultural products, advanced coatings and composites and microbial control solutions that combat dangerous viruses, bacteria and other pathogens.

Founded in 1897 in the Swiss Alps, Lonza today is a well-respected global company with more than 50 major manufacturing and R&D facilities and nearly 14,000 full-time employees worldwide. Further information can be found at

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