• The New York Giants' wide receivers took a beating in Week 5. Odell Beckham Jr. is done for the year with a broken ankle. Brandon Marshall is out for the year with an ankle injury, and Dwayne Harris is out for the season with a fractured foot. Sterling Shepard also suffered an ankle injury and is day to day.
• Kansas City Chiefs tight end Travis Kelce suffered a possible concussion and didn't play during the second half of Week 5. Also, Buffalo Bills tight end Charles Clay will miss multiple weeks with a knee injury.
• The Houston Texans defense took two major hits, as defensive end J.J. Watt has been diagnosed with a left tibial plateau fracture and linebacker Whitney Mercilus suffered torn pectorals. Both are expected to miss the remainder of the season.